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Molecular
Biology of Neural Stem Cells
Neural stem cells are primitive progenitor cells that can
both self-renew, and differentiate to various classes of neurons
and glia. We are interested in the molecules and mechanisms that
control the self-renewal and differentiation of stem cells in
both the peripheral and central nervous system. Our approach encompasses
microarray and subtractive hybridization to identify novel candidate
regulators of stem cell fate, and loss- and gain-of-function genetic
manipulations both in vitro and in vivo.
Recent publications
Deneen, B., Ho, R., Lukaszewicz, A., Hochstim, C. J., Gronostajski, R. M., and Anderson, D. J. (2006). The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron 52, 953-68. [Pubmed]
Mukouyama, Y. S., Deneen, B., Lukaszewicz, A., Novitch, B.G., Wichterle, H., Jessell, T. M., and Anderson, D. J. (2006). Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo.
Proc Natl Acad Sci U S A 103, 1551-6..
[Pubmed]
Gabay, L., Lowell, S., Rubin, L. L. and Anderson, D. J. (2003). Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro. Neuron 40, 485-99.
[Pubmed] [F1000 factor 6.0 ] [see commentary]
Kim, J., Lo, L., Dormand, E. and Anderson, D. J. (2003). SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells. Neuron 38, 17-31.
[Pubmed] [F1000 factor 3.0]
Zhou, Q. and Anderson, D. J. (2002). The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 109, 61-73.
[Pubmed]
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Molecular
Biology of Neural Stem Cells
Neural Circuitry of
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For Pain
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