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Neural Circuitry
of Fear
Fear is a highly conserved emotion with specific behavioral
expressions. A great deal has been learned about neural circuits
for learned (conditioned) fear, but much less is known about circuits
for unlearned (innate or unconditional) fear. We are interested
in the relationship between the neural circuits mediating learned
and innate fear. We have defined behavioral assays to compare
these two types of fear using similar stimuli, and are developing
molecular genetic tools to functionally manipulate the underlying
neural substrates. An elucidation of neural circuits for fear
is a pre-requisite for understanding how genes, drugs and experience
act on and modify these circuits, in both normal behavior and
in affective disorders such as anxiety and depression.
Recent publications
Lerchner, W., Xiao, C., Nashmi, R., Slimko, E.M., van Trigt, L., Lester, H.A., and Anderson, D.J. (2007). Reversible silencing of neuronal excitability in behaving mice by a genetically targeted, ivermectin-gated Cl- channel. Neuron 54, 35-49. [Pubmed]
Choi, G. B., Dong, H. W., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Swanson, L. W., and Anderson, D. J. (2005). Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus. Neuron 46, 647-60.
[Pubmed] [Commentary]
Han, C. J., O'Tuathaigh, C. M., van Trigt, L., Quinn, J. J., Fanselow, M. S., Mongeau, R., Koch, C. and Anderson, D. J. (2003). Trace but not delay fear conditioning requires attention and the anterior cingulate cortex. Proc Natl Acad Sci U S A 100, 13087-92.
[Pubmed] [F1000 factor 6.0]
Mongeau, R., Miller, G. A., Chiang, E. and Anderson, D. J. (2003). Neural correlates of competing fear behaviors evoked by an innately aversive stimulus. Journal of Neuroscience 23, 3855-68. [Pubmed]
Zirlinger, M. and Anderson, D. (2003). Molecular dissection of the amygdala and its relevance to autism. Genes Brain Behav 2, 282-94.
[Pubmed]
Zirlinger, M., Kreiman, G. and Anderson, D. J. (2001). Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei. Proc Natl Acad Sci U S A 98, 5270-5.
[Pubmed]
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Molecular
Biology of Neural Stem Cells
Neural Circuitry of
Fear
Molecules and Pathways
For Pain
Genes and Neural Circuits
For Innate Behaviors in Fruit Flies
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